Comment · Wed, June 19, 2019 · Natrium Health & Nootropics Depot
I just discovered a NATURAL Dopamine (D2) Agonist + DRI
Original post in this thread
Lokzo55 · 44 points
LAURELIA NOVAE-ZELANDIE EXTRACT (-PUKATEA-).
Māori used the bark of the tall pukatea (Laurelia novae-zelandiae) tree as a painkiller, boiling the inner layer to make a decoction. Pulped inner bark was also held in the mouth to ease toothache. Pukatea bark contains pukateine, which has a chemical structure similar to morphine. It was first isolated in 1910 by Bernard Aston, the first chemist at the Department of Agriculture.
Pukatea is supposedly an analgesic similar to morphine (Similar chemical structure).
This herb contains a Pukateine which is a D1/2 receptor agonist (IC50: 0,4/0,6 muM) but also a dopamine reuptake inhibitor with an IC50 of 46muM.
The D2 receptor agonism (like LSD, Salvinorin A and anti-parkinson drugs) may explain the reported dissociative effects.
It also shows alpha1-adrenoceptor affinity and antioxidant activity.
I have personally not trialled this herb for any purposes, however, it has piqued my interest.
Let's get some discussion going!
What they were answering
Lokzo55 · 1 points
Hopefully we see this on the market in some years from now ;)
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
I just tried tetrahydropalmatine last night. It knocked me out. However, I am really groggy now. This is what I expected from it, based on its affinities. It will help you get to sleep, for sure. I don't think I got quality sleep, though. The D2 receptor is an interesting one. I'll see if I can get some pukatine to compare.
Memantine is an agonist at D2. I know what that feels like.