Comment · Sat, February 16, 2019
R-ALA cyclodextrin dosing
Original post in this thread
Hywardhayward · 1 points
Hi,
According to Ikuta et al. in "Bioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926482/#!po=22.0588)
6g of R-ALA Cy is equivalent to only 600mg of Na-R-ALA. The reccomended dosing of R-ALA Cy according to ND is 500mg. If you see table 2 and chart 2 you can see to get the increased bioavailability benefits of R-ALA Cy still requires a larger dose of powder, I think it means more of the total powder weight is the cyclodextrin complex vs. smaller weight of sodium content of Na-R-ALA. So while the actual R-lipoic acid is better uptaken when in cyclodextrin complex, the fraction of each mg of R-a-lipoic acid in Na-R-ALA is way higher, i think only 5% is sodium, while the cyclodextrin appears to take up 90% of each mg of powder.
If you took 500mg of R-ALA Cy, you would only need 125mg of Na-R-ALA to match the bioavailability, even taking into account the 2.5x increased bioavailability of cyclodextrin form because there is just so little actual lipoic acid and so much cyclodextrin taking up space in the powder.
This means the R-ALA Cy needs to be dosed at a prohibitively expensive amount, using 10…
What they were answering
Hywardhayward · 2 points
Got it. I mostly wanted to confirm if the dosing equivalency stated in the paper actually applied. I was not sure if there was some difference with your product and the one in the research, because of the 500mg reccomended dose on the ND website. Thanks for the great answer.
I see you now have taurine, which is good. I would also buy free form glycine from your company if you carried it.
u/MisterYouAreSoDumb
My pleasure! We can look into glycine. We are going to be selling N-methylglycine (Sarcosine) soon. So we can possibly add in glycine powder as well. I'll talk to the team about it.