Comment · Thu, April 12, 2018 · Ceretropic & Nootropics Depot
Need some help interpreting a paper on Kratom.
Original post in this thread
Aikinator · 6 points
The paper.
>Physiological study further supported the effects of M. speciosa on the cognition. The methanolic extract of M. speciosa was found to produce an irreversible reduction of field excitatory post-synaptic potentials (fEPSP) amplitude with an IC50 of 0.008% in the hippocampal slices of rats. The methanolic extract of M. speciosa at 0.008% also inhibited long term potentiation (LTP) induction but induced a short-term potentiation. LTP is considered to underlie the learning and memory processes in the brain (Hansen andManahanVaughan, 2015, Shapiro, 2001; Martin and Morris, 2002). Therefore, the finding may elucidate one of the mechanisms underlying the memory-impairing effects of M. speciosa (Senik et al., 2012a).
What does the irreversible part mean?
What they were answering
kingkahjj · 1 points
Does it say what dose kratom impairs cognition at?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Not really, no. This is in rats, and they are using concentrated extracts. So it's not really possible for us to accurately extrapolate equivalent dosages of powdered kratom in humans. I will say that most studies that try to assess significant results use very high dosages. That's because they want to reach statistically significant results, which is more likely with higher dosages. However, I can't give you a human dosage in grams that I would be confident in saying is the threshold. It would be a total shot in the dark.