Comment · Thu, April 12, 2018 · Ceretropic & Nootropics Depot
Need some help interpreting a paper on Kratom.
Original post in this thread
Aikinator · 6 points
The paper.
>Physiological study further supported the effects of M. speciosa on the cognition. The methanolic extract of M. speciosa was found to produce an irreversible reduction of field excitatory post-synaptic potentials (fEPSP) amplitude with an IC50 of 0.008% in the hippocampal slices of rats. The methanolic extract of M. speciosa at 0.008% also inhibited long term potentiation (LTP) induction but induced a short-term potentiation. LTP is considered to underlie the learning and memory processes in the brain (Hansen andManahanVaughan, 2015, Shapiro, 2001; Martin and Morris, 2002). Therefore, the finding may elucidate one of the mechanisms underlying the memory-impairing effects of M. speciosa (Senik et al., 2012a).
What does the irreversible part mean?
What they were answering
Aikinator · 1 points
Are you talking about short-term effects?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
I would be more likely to believe that kratom impairs cognition temporarily in the short-term than I would believe it irreversibly impairs it in the long-term. Is that what you are asking?