Comment · Thu, April 12, 2018 · Ceretropic & Nootropics Depot
Need some help interpreting a paper on Kratom.
Original post in this thread
Aikinator · 6 points
The paper.
>Physiological study further supported the effects of M. speciosa on the cognition. The methanolic extract of M. speciosa was found to produce an irreversible reduction of field excitatory post-synaptic potentials (fEPSP) amplitude with an IC50 of 0.008% in the hippocampal slices of rats. The methanolic extract of M. speciosa at 0.008% also inhibited long term potentiation (LTP) induction but induced a short-term potentiation. LTP is considered to underlie the learning and memory processes in the brain (Hansen andManahanVaughan, 2015, Shapiro, 2001; Martin and Morris, 2002). Therefore, the finding may elucidate one of the mechanisms underlying the memory-impairing effects of M. speciosa (Senik et al., 2012a).
What does the irreversible part mean?
What they were answering
Aikinator · 1 points
I mean the short-term impairment on higher doses is self-evident when you take kratom. I am more concerned with the potential long-term effects on cognition.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
I'd say this study raises concerns, but is far from conclusive evidence for any long-term cognitive impairment from kratom use in humans. I'd also say it is reasonable to assume that large doses over long periods would lead to a higher risk of memory impairments, if they exist in humans. So keeping your dosages lower and taking breaks is advisable if you are concerned about these possible risks.