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Comment · Tue, November 29, 2016 · Ceretropic & Nootropics Depot

What causes DXM's afterglow effect?

Original post in this thread

baccheion · 6 points

Serotonin? Opioid receptors interactions? Upregulation after NMDA antagonism? Something else?

Maybe there'll be some combination of supplements I can take to mimic/recreate this effect.

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

The Sigma-1 receptors play a role in that.

Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.

The Pharmacology of Sigma-1 Receptors

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