Comment · Thu, November 10, 2016 · Ceretropic & Nootropics Depot
Has anyone utilized DA agonists long term(>2 weeks)? What has been your experience with their effects on mood?
Original post in this thread
hootnoot · 12 points
It has been shown that DA agonists have an effect on hedonic difficulties and depression. See below.
https://www.ncbi.nlm.nih.gov/pubmed/6751339
https://www.ncbi.nlm.nih.gov/pubmed/6172006
https://www.ncbi.nlm.nih.gov/pubmed/9295183
https://www.ncbi.nlm.nih.gov/pubmed/17187269
https://www.ncbi.nlm.nih.gov/pubmed/15999953
https://www.ncbi.nlm.nih.gov/pubmed/16814808
https://www.ncbi.nlm.nih.gov/pubmed/7871089
https://www.ncbi.nlm.nih.gov/pubmed/16959244
Any experiences?
Logically, DA agonists that are agonists both pre-synaptically and post-synaptically active will be aversive and generally shitty to begin with, that's a given. Sedation, fatigue, nausea are expected with DNsh agonism as these are autoreceptors that inhibit neurotransmission upon agonism. However, agonising D2L, for example, has been shown to be nootropic, mood enhancing, motivational and so forth. In-fact, there is a direct correlation between D2L expression and an array of pro-cognitive, mood and social effects. The problem with most DA agonists is an an affinity for both pre and post synaptic receptors. I speculate that upon down-regulation of the pre autoreceptors, with usage of >1 week, these drugs…
What they were answering
hootnoot · 2 points
I didn't mean to sell but to trial tbh. I'm well aware of its patent and POM classification. Since its still under patent and mostly US based it's expensive and hard to source for the poor inquisitive folks abroad such as myself.
That said, it has a decent profile for achieving antidepressant effects without the usual numbing/apathy/anhedonia. I don't get the single approach on marketing it as a female viagra only, but it appears to have failed if you look at its reception.
If someone could make something as similar to Mirtazapine, with no histamine binding and tighter binding for adrenergic and serotonergic receptors they'd have themselves a pretty stimulating(but not in the same realm as a stimulant that reverses transporters and releases) and sustainable antidepressant. Of-course, with GLYX and NRX on the horizon there'd be no point starting now if you were a pharma company but still. Btw, did anyone ever elucidate the synthesis of GLYX/NRX? I know there were attempts at a group buy but the synthesis fell flat?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
I am not sure on the GLYX/NRX front. I kind of kept out of that for the time being. It's rather difficult to get labs to take on new complex syntheses like that. There is not a lot of money in it for them, when they can spend their time on easier synths with a larger market to sell to.