Comment · Wed, November 9, 2016 · Ceretropic & Nootropics Depot
Has anyone utilized DA agonists long term(>2 weeks)? What has been your experience with their effects on mood?
Original post in this thread
hootnoot · 12 points
It has been shown that DA agonists have an effect on hedonic difficulties and depression. See below.
https://www.ncbi.nlm.nih.gov/pubmed/6751339
https://www.ncbi.nlm.nih.gov/pubmed/6172006
https://www.ncbi.nlm.nih.gov/pubmed/9295183
https://www.ncbi.nlm.nih.gov/pubmed/17187269
https://www.ncbi.nlm.nih.gov/pubmed/15999953
https://www.ncbi.nlm.nih.gov/pubmed/16814808
https://www.ncbi.nlm.nih.gov/pubmed/7871089
https://www.ncbi.nlm.nih.gov/pubmed/16959244
Any experiences?
Logically, DA agonists that are agonists both pre-synaptically and post-synaptically active will be aversive and generally shitty to begin with, that's a given. Sedation, fatigue, nausea are expected with DNsh agonism as these are autoreceptors that inhibit neurotransmission upon agonism. However, agonising D2L, for example, has been shown to be nootropic, mood enhancing, motivational and so forth. In-fact, there is a direct correlation between D2L expression and an array of pro-cognitive, mood and social effects. The problem with most DA agonists is an an affinity for both pre and post synaptic receptors. I speculate that upon down-regulation of the pre autoreceptors, with usage of >1 week, these drugs…
What they were answering
hootnoot · 2 points
Wait n- I mean, I don't know. For science right?
Haha, but seriously, check this.
https://www.ncbi.nlm.nih.gov/pubmed/9537806
It makes sense, too. Like Mirtazapine without the dirt.
I've been looking for a 5-HT 2A/2C/3/7 antagonist...why has no one made these? I suppose the above is a decent compromise.
Any thoughts?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Well it's prescription only, patented, and the FDA tried to keep it from market as much as they could. So it is a risky one to sell.