Comment · Fri, September 30, 2016 · Ceretropic & Nootropics Depot
Magnesium-25 As A Nootropic And True Enhancer Of Cellular Metabolism
Original post in this thread
PeopleProgrammer · 92 points
http://www.sciencedirect.com/science/article/pii/S0223523408003498?np=y
http://pubs.acs.org/doi/abs/10.1021/jp710989d
Due to it's nuclear spin, magnesium-25 is 2.5x as efficient at catalyzing the synthesis of ATP and stabilizing it in the cytosol, than the 9x more abundant isotope; magnesium-24 which has no nuclear spin. Many people are already deficient in magnesium due to a diet high in processed foods. supplementing with isotopically enriched magnesium (meaning more Mg-25 than the naturally more common Mg-24), could provide a strong stimulant effect rather than traditional depressant role of large doses of Mg^2+ displacing Ca^2+ from its ion channel, and result in dramatically increased metabolism and improved functioning in each cell in the body. I incidentally ran into this as I was researching how I could actually put my rational design project into a GMO cell culture line.
What they were answering
PeopleProgrammer · 1 points
I dont mean to sound rude, but couldnt you just isolate a salt (or more practically, an organometallic complex) of 25-Mg in house?
Theoretically, all you would need to do is get some metallic magnesium and react it with L-threonine, or the organic compound of your choice and limit the reaction to ~11% of the moles of magnesium. since the nuclear spin of 25-Mg renders it much more reactive (due to the effect on the spin of it's electrons) than 24-Mg or 26-Mg, that 11% of the magnesium that actually complexes will be mostly 25-Mg. Then just separate out the unreacted magnesium 24 and 26, by dissolving the complex in solution.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Theoretical and practical are two totally different things. I actually found a supplier of Mag-25. However, can we even take elemental magnesium-25 and have it be orally bioavailable? Wouldn't we still need to chelate it for oral use?