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Comment · Thu, July 21, 2016 · Ceretropic & Nootropics Depot

New Products at Nootropics Depot

Original post in this thread

zifzif · 25 points

Whenever I get the Nootropics Depot newsletter I get all giddy, and my wallet runs in fear.

First off is a new Bacopa extract called Synapsa. Does anybody here have experience with both Synapsa AND Bacognize? I like Bacopa, but ultimately discontinued after 5 months due to lethargy and brain fog. Hoping someone can corroborate what I've read: that Synapsa is a bit more stimulating.

Second question is directed primarily at u/MisterYouAreSoDumb, but I think others will wonder the same. Cordyceps 10:1 extract from Nammex was also released today, with 20% beta glucans and 0.3% cordycepin by HPLC. Upon checking the original Cordyceps page, I see that it, too has 0.3% cordycepin, but 30% beta glucans. It would appear that the original is more potent-- is this true?

All input on both questions welcome.

What they were answering

JesleyH · 1 points

I just wanted to ask you about this I read some time ago.

One person claimed much of neuroprotective properties of bacopa are mediated by its antidopaminergic effect. So a dopamine precursor would make pointless to take bacopa, how true is this?

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

No, that's not right. Bacopa prevents the degeneration of dopaminergic neurons, along with lipid peroxidation. It actually modulates the expression of dopaminergic receptors up and down. It's also an acetylcholine stearase inhibitor. So the neuroprotective properties of bacopa are from preventing oxidative stress. It also has a modulating effects on dopamine receptors. So you can certainly still take a dopamine precursor with it. It's not going to affect the neuroprotection of it.

Neuroprotective Potential of Bacopa monnieri and Bacoside A Against Dopamine Receptor Dysfunction in the Cerebral Cortex of Neonatal Hypoglycaemic Rats

Anti-Parkinsonian effects of Bacopa monnieri: Insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson’s disease

Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture

Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain

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