Comment · Sun, June 12, 2016 · Ceretropic & Nootropics Depot

Which nootropic can upregulate GABA A receptor?

Original post in this thread

homosuperiorr · 3 points

How to decrease clonazepam tolerance?

Tolerance results in a desensitization of GABA receptors and an increased sensitization of the excitatory neurotransmitter system, glutamate such as NMDA glutamate receptors.

Other changes that occur are the reduction of the number of GABA receptors (downregulation).

https://en.wikipedia.org/wiki/Benzodiazepine_dependence#Mechanism

So GABA A antagonist and/or GABA A upregulator and NMDA antagonsit would work, yes?

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

Kava has been shown to up-regulate GABAa.

Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain.

Neuroprotective properties of kavalactones

Bacopa up-regulates GABAa too.

Molecular and functional characterization of Bacopa monniera: a retrospective review

Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieriand Bacoside-A

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