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Comment · Sun, June 12, 2016 · Ceretropic & Nootropics Depot

Which nootropic can upregulate GABA A receptor?

Original post in this thread

homosuperiorr · 3 points

How to decrease clonazepam tolerance?

Tolerance results in a desensitization of GABA receptors and an increased sensitization of the excitatory neurotransmitter system, glutamate such as NMDA glutamate receptors.
Other changes that occur are the reduction of the number of GABA receptors (downregulation).

https://en.wikipedia.org/wiki/Benzodiazepine_dependence#Mechanism

So GABA A antagonist and/or GABA A upregulator and NMDA antagonsit would work, yes?

What they were answering

homosuperiorr · 1 points

Thanks for responding! And I have a question not much related to the topic. When will you release that new products and P21 that you promised to? I'm planning quite a big order, and only waiting for them. And also PQQ, you said that you will go with it on Nootropic Depot, when?

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

We are getting close to being able to relaunch. I know I have said that a while, but this time is more promising.

I don't have a date for the PQQ on ND yet. I would imagine sometime in the next 3-4 months.

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