Comment · Fri, March 25, 2016
What they were answering
meatball4u · 1 points
Very good to know. I likely have significant chronic mitochondrial dysfunction. As an aside, does modafanil disrupt mito function?
u/MisterYouAreSoDumb
Modafinil actually increases mitochondrial membrane potential, and is neuroprotective in some cases.
Comment · Fri, March 25, 2016 · 5 pts
[MDMA \(ecstasy\) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers](https://mega.nz/#!xMJD1CDB!-80uy8qKs7MR-Pq4fLMmc0M1qYDJNxb-eCyT1g62YAM) >Evidence that individuals possessing a
Comment · Fri, March 25, 2016 · 7 pts
A real allergy is a hypersensitivity of one's immune system to a certain compound. It's an immune/inflammatory response to an exogenous substance. I would not consider being a poor metabolizer of something to be an aller
Comment · Fri, March 25, 2016 · 3 pts
Yeah, MDMA has been shown to disrupt mitochondrial function acutely. However, it returns to control levels within 24 hours. Taking some supplements that support the electron transport chain, like CoQ10, ALCAR, PQQ, etc.
Comment · Sat, March 26, 2016 · 1 pts
Yes, taking a small initial dose of a new compound is always advisable. Alexander Shulgin did that with every new compound he investigated. It's better to be safe than sorry.
Comment · Sat, March 26, 2016 · 2 pts
Yep, that is a good analogy. Lactose intolerance is an interesting subject on its own too. Your body produces the enzyme when you are young, and keeps doing it if exposure to lactose is consistent. However, if you stop
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