Comment · Thu, January 21, 2016 · Ceretropic & Nootropics Depot
Gaba-B agonists, dopamine feed back loop, NMDARs, BDNF... Help me connect the dots
Original post in this thread
Yoyomamahh · 24 points
TLDR at bottom
-Background-
To make a long story short, I tried phenibut and it changed my life. It made my mind clear, my mood sharp, my emotional intelligence skyrocket, and just gave me a "happy to be alive" type feeling. Up to that point I didn't even know how amazing the gift of life really was. I thought my Aspergerger symptoms were just my vote personality. I didn't realize my emotional instability, sensory problems, social anxiety, brain fog, low energy levels, irritability, and a shit ton of other symptoms could be resolved.
During this time I was a freshman in college. Never been on a date, socially awkward as fuck, couldn't make eye contact, and would turn red as a pepper any time attention was brought to me. I had tried recreational drugs to try and help, none of which I really enjoyed. Phenibut changed all this for about 12 hours.
Unfortunately we all know about its tolerance and withdrawals. But shit I just knew that somehow, someway, this random Russian gem cured me and set my soul free. I could walk anywhere with my head up, joke around, freely express my opinion, flirt with girls, and face my fears.
The most convincing thing (and what made me believe this…
What they were answering
Yoyomamahh · 1 points
I understand. The sleep depravation thing happened once, but I have experienced the same feeling without sleep deprivation numerous times. For over a year, at least once a week, usually twice, but notice these effects every time I do it. The weird thing is, if I take the 2 drugs together it does not have this effect. Only during an adderall comedown.
And I haven't tried nefiracetam, I might just order some tonivht. I have d-cycloserine now, would that have the same effect? If the feeling is sustainable, could low dose adderall early in the am+ Baclofen in the afternoon be a solution? I can't help but think that maybe I'm really messing up the dopamine in my brain, or is it actually a benefit with the Baclofen?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
D-Cycloserine is actually partial agonist of the glycine site. So it activates the glycine site, but to a lower extent than glycine. It lowers activation compared to homeostasis, just not as much as a full antagonist would.
It is an interesting reaction; especially that is is reproducible. It could be an interaction we are not thinking about too. It's hard to say.