Comment · Thu, January 21, 2016 · Ceretropic & Nootropics Depot
Gaba-B agonists, dopamine feed back loop, NMDARs, BDNF... Help me connect the dots
Original post in this thread
Yoyomamahh · 24 points
TLDR at bottom
-Background-
To make a long story short, I tried phenibut and it changed my life. It made my mind clear, my mood sharp, my emotional intelligence skyrocket, and just gave me a "happy to be alive" type feeling. Up to that point I didn't even know how amazing the gift of life really was. I thought my Aspergerger symptoms were just my vote personality. I didn't realize my emotional instability, sensory problems, social anxiety, brain fog, low energy levels, irritability, and a shit ton of other symptoms could be resolved.
During this time I was a freshman in college. Never been on a date, socially awkward as fuck, couldn't make eye contact, and would turn red as a pepper any time attention was brought to me. I had tried recreational drugs to try and help, none of which I really enjoyed. Phenibut changed all this for about 12 hours.
Unfortunately we all know about its tolerance and withdrawals. But shit I just knew that somehow, someway, this random Russian gem cured me and set my soul free. I could walk anywhere with my head up, joke around, freely express my opinion, flirt with girls, and face my fears.
The most convincing thing (and what made me believe this…
What they were answering
JohnTorque · 1 points
Wouldn't NMDA agonists fit better for OP case? Things like D-aspartic acid are helpful for bipolar and schizos, and this fits in NMDA hypo function theory.
I'm ignorant about this gaba balance, but wouldn't GABA agonists lead to less NMDA function?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Well yes and no. If OP's issues are due to dysfunction of the NMDAR-NR1, then a glycine-site NMDA modulator like GLYX-13, NRX-1074, or Neifracetam could help some aspects of it. However, they might also cause anxiety. The theory about GABA(B) agonists is that they bring the balance on inhibitory/excitatory signaling back into balance, which actually lowers the excitability of pyramidal neurons, and reduces the static in one's thoughts. It's not so much a lack of signaling, but an imbalance, causing dysfunction of the focus of thoughts.