Comment · Fri, January 8, 2016 · Ceretropic & Nootropics Depot
Can anyone help explain the mechanism for which excess Choline can cause mood disturbances? (e.g depression)
Original post in this thread
gitfetchmorecoffee · 16 points
I am trying to find more information pertaining to exact mechanism excess Choline has which causes many people to have mood disturbances. I have not been able to find any particular studies on this matter, though I have seen it mentioned, and have seen speculation that it is somehow related to dopamine in one way or another.
The thing that really interests me, is that it seems to be an issue with all types of exogenous Choline(including CDP-choline which is interesting in itself, as CDP-choline has been shown to increase dopamine receptor density), and even AChE Inhibitors such as Aricept(Donepezil).
Could anyone help explain what exactly is going on here? It seems that this is most evident when users over-dose Choline sources, but I am looking for the reason it has such a profound effect on a users mood.
What they were answering
cosmicrush · 1 points
I am being naive by saying this, but I believe all visual distortions come down to glutamate signaling.
Psychedelics modulation of 5HT2a causes inhibition of mglu receptors and then this disbalances AMPA NMDA and Kainate.
Dissociatives cause AMPA and mglu to increase by inhibiting GABA release through NMDA blocking.
I feel that either distortions occur with de synchronization of the two sides of vision like the actual visual reception and then perception separately.
Or that a decrease in any glutamate receptor's activity and frequency leads to lowered frame rate. This then is effected by stroboscopic effects like melting and such. This can happen with video recorders as well. It's like those early animation toys where you spin the wheel. The frame rate of the perception vs frame rate of the vision will have a detuning effect. Chorus. Or flanging. If you know music lol.
Also fractals seem to occur similar as white noise. If you imagine each neuron is firing out of sync. Each pixel is at a different phase. But if they are in sync then they appear connected. Strobe lights actually induce fractals. Sorry for being repetitive. I'm a nerd. Ugh.
But imagine that melting walls is the white noise of motion. Imagine that objects becoming one is just white noise of line detection or object recognition. And also apply not just white noise but also synchronization effects as we…
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
It's an interesting hypothesis. Glutamate receptors are expressed in the retina, and certainly altered glutamate levels in the visual cortex of the brain could affect how you perceive visuals. Muller cells and photoreceptors in the eyes contain glutamate.