Comment · Sat, January 9, 2016 · Ceretropic & Nootropics Depot
Can anyone help explain the mechanism for which excess Choline can cause mood disturbances? (e.g depression)
Original post in this thread
gitfetchmorecoffee · 16 points
I am trying to find more information pertaining to exact mechanism excess Choline has which causes many people to have mood disturbances. I have not been able to find any particular studies on this matter, though I have seen it mentioned, and have seen speculation that it is somehow related to dopamine in one way or another.
The thing that really interests me, is that it seems to be an issue with all types of exogenous Choline(including CDP-choline which is interesting in itself, as CDP-choline has been shown to increase dopamine receptor density), and even AChE Inhibitors such as Aricept(Donepezil).
Could anyone help explain what exactly is going on here? It seems that this is most evident when users over-dose Choline sources, but I am looking for the reason it has such a profound effect on a users mood.
What they were answering
Debonaire_Death · 1 points
I think a similar mechanism is responsible for the emotional hyperliquidity many experience on racetams. This is also why I think piracetam has the most comprehensive effects; the lower potency and BBB permeability mean it is far more perfuse in the PNS than any other racetam, which would also explain it's laxative effects, as it would act much more on the enteric nervous system.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Well we know peripheral adrenergic signaling is crucial to Piracetam's effects, so I would not doubt it.