Comment · Mon, December 28, 2015 · Ceretropic & Nootropics Depot
Is anyone selling tianeptine SULFATE besides Ceretropic?
Original post in this thread
SickleInThePickle · 30 points
Not talking about the sodium version; everyone and their mother is selling that. As great as Ceretropic is, more vendors will naturally lead to competitive pricing. Is anyone selling the sulfate besides Ceretropic?
What they were answering
Jackolysis · 1 points
So I found the average release rate for the first four hours from the simulated gastric acid data in the patent see table 7 and 8 here was the result. All in %/h
Sulfate 1: 13.84242424 Sodium 1: 15.15223327
Sulfate 2: 10.0678571 Sodium 2: 13.01170552
Sulfate 3: 7.028249895 Sodium 3: 9.90913549
On average the Sodium releases at a 2.38 %/h rate faster than the sulfate in the first 4 hours. This is not a large enough difference to double the dose.
Of course this is all in CR tablets and simulated gastric acid. But it's the closest to a comparative pharmacokinetics study there is.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
That's the release rate, not the absorption rate. We cannot really compare the two. I agree that the dose should not be adjusted using the patent data. We have to go on anecdotal data for now. Based on the anecdotes of countless people, there is a big difference in the speed of absorption and the time to lose effects. Most people play around with the dosages of both salts to find what works best for them. The safest method would be to take the standard 12.5mg dose, and adjust it for the larger molar mass of the H2SO4. So starting at 15mg would be prudent. The issue is that most people who do that find that dose to be too low. So they adjust up until they get the desired effects. So far that seems to be roughly at 25mg. Again, some people use more, just like some people use more of the sodium. However, I have spoken to a ton of people that relay to me that the sulfate is much less peaky in effects, and consequently less prone to abuse. It should just not be stated as a scientifically proven fact, till some pharmacokinetic studies can be run.