One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition (2015)

Comment · Thu, September 3, 2015 · 12 pts

You can make good friends who will not judge you. You can also develop the skill of not caring what people think. It may take time to find someone you really connect with, and who accepts you for exactly who you are. How

Comment · Thu, September 3, 2015 · 10 pts

There is always a future, if you keep looking forward. You will not see the amazing things on the horizon if you are always looking back. Take it from someone that almost ended their life on a number of occasions. Whatev

Comment · Thu, September 3, 2015 · 3 pts

Yeah, I read that study too. It showed that bullies have high reported self-esteem. However, other studies have shown bullies are actually very prone to issues with shame. They are shameful if there is something going wr

Comment · Fri, September 4, 2015 · 1 pts

True. When you get to the point of not letting what other people think affect you, the reasoning behind why they think/act the way they do is irrelevant to your progress. However, it is not irrelevant to the situation as

Comment · Fri, September 4, 2015 · 2 pts

Ohh, well that's a different problem. Have any nootropics or other substances helped with the anhedonia at all?

Comment · Fri, September 4, 2015 · 6 pts

Anything can look bad if you let it. Similarly, anything can be painted in a better light if you choose to. The biggest thing I have learned over the years is that happiness is a choice. A difficult choice at times, but

Comment · Sat, September 5, 2015 · 1 pts

What all have you tried so far?

Comment · Sun, September 6, 2015 · 2 pts

Yeah, Agomelatine is pretty subtle in the 5-HT2C department. I am going to try and work on brining out a selective 5-HT2C antagonist with higher affinity. I have not decided on a compound yet, though.

Comment · Tue, September 8, 2015 · 1 pts

Interesting. So do you find antihistamines make your anhedonia worse?

Comment · Tue, September 8, 2015 · 1 pts

Have you tried Pitolisant? It's an H3 inverse agonist. It increases brain histamine levels, without the peripheral side effects.

Comment · Wed, September 9, 2015 · 1 pts

No, it acts on the histamine system. I do not believe it has any 5-HT2C affinities. However, it would be interesting to see how increasing brain histamine would affect you, since you say antihistamines make your anhedoni

Comment · Wed, September 9, 2015 · 1 pts

What about SB-242084? GlaxoSmithKline was working on it.

Comment · Wed, September 9, 2015 · 1 pts

I have not seen anything recently on it.

Comment · Thu, September 10, 2015 · 1 pts

I certainly can. I just have not, due to the difficulties in using it. It's not very water soluble without a counterion.