One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition (2015)

Comment · Thu, September 3, 2015 · 10 pts

There is always a future, if you keep looking forward. You will not see the amazing things on the horizon if you are always looking back. Take it from someone that almost ended their life on a number of occasions. Whatev

Comment · Thu, September 3, 2015 · 3 pts

Yeah, I read that study too. It showed that bullies have high reported self-esteem. However, other studies have shown bullies are actually very prone to issues with shame. They are shameful if there is something going wr

Comment · Fri, September 4, 2015 · 1 pts

True. When you get to the point of not letting what other people think affect you, the reasoning behind why they think/act the way they do is irrelevant to your progress. However, it is not irrelevant to the situation as

Comment · Fri, September 4, 2015 · 2 pts

Ohh, well that's a different problem. Have any nootropics or other substances helped with the anhedonia at all?

Comment · Fri, September 4, 2015 · 1 pts

That looks like a sick base-jumping cliff ahead! I bet you there is a badass cave at the bottom of that cliff too!

Comment · Fri, September 4, 2015 · 6 pts

Anything can look bad if you let it. Similarly, anything can be painted in a better light if you choose to. The biggest thing I have learned over the years is that happiness is a choice. A difficult choice at times, but

Comment · Sat, September 5, 2015 · 1 pts

What all have you tried so far?

Comment · Sun, September 6, 2015 · 2 pts

Yeah, Agomelatine is pretty subtle in the 5-HT2C department. I am going to try and work on brining out a selective 5-HT2C antagonist with higher affinity. I have not decided on a compound yet, though.

Comment · Tue, September 8, 2015 · 1 pts

Interesting. So do you find antihistamines make your anhedonia worse?

Comment · Tue, September 8, 2015 · 1 pts

Have you tried Pitolisant? It's an H3 inverse agonist. It increases brain histamine levels, without the peripheral side effects.

Comment · Wed, September 9, 2015 · 1 pts

No, it acts on the histamine system. I do not believe it has any 5-HT2C affinities. However, it would be interesting to see how increasing brain histamine would affect you, since you say antihistamines make your anhedoni

Comment · Wed, September 9, 2015 · 1 pts

What about SB-242084? GlaxoSmithKline was working on it.

Comment · Wed, September 9, 2015 · 1 pts

I have not seen anything recently on it.

Comment · Thu, September 10, 2015 · 1 pts

I certainly can. I just have not, due to the difficulties in using it. It's not very water soluble without a counterion.