Comment · Tue, July 7, 2015 · Ceretropic
semax/selank and μ-opioid agonists (ie, tianeptine) report
Original post in this thread
nakedproof · 4 points
I've have a few bad experiences with semax(and others like na-semax-amidate), selank and μ-opioid agonists (tianeptine and tramadol specifically). I become very terse, aggressive and irritated with this combination.
I was surprised when I became agitated when I took tianeptine and semax together (12mg tianeptine and ~400mcg semax nasal spray), but thought I was just having an off day. I also had another experience with na-semax (may have been amidate, I dont remember) and 30mg of tianeptine which ended in me trying to drink the irritation away)
I also had an experience with about 12mg of tramadol and na-selank which resulted in the same sort of mental/emotional discomfort and irritation.
That's all, if anyone has had similar experiences or may have an explanation, feel free to comment
What they were answering
Debonaire_Death · 1 points
Thanks! That's interesting: I read the study about SEMAX and 5-HT/DA and it's very interesting that the 5-HT increase was relatively insignificant in comparison with the 5-HIAA increase. Based on the results it would seem that the drug increases MAO-A activity. That is likely why I benefited so dramatically from it: I have low-functioning MAO-A.
If I had the lab for it, I would start drawing up an experiment right now to see if SEMAX could reverse the effects of an MAOI on 5-HT and 5-HIAA levels. I already have a little confirmation bias cooking on the back burner, though ; )
u/MisterYouAreSoDumb · Ceretropic
It is certainly a complex mechanism. The melanocortin/opioid/dopamine interactions are very interesting.