Comment · Mon, July 6, 2015 · Ceretropic
semax/selank and μ-opioid agonists (ie, tianeptine) report
Original post in this thread
nakedproof · 4 points
I've have a few bad experiences with semax(and others like na-semax-amidate), selank and μ-opioid agonists (tianeptine and tramadol specifically). I become very terse, aggressive and irritated with this combination.
I was surprised when I became agitated when I took tianeptine and semax together (12mg tianeptine and ~400mcg semax nasal spray), but thought I was just having an off day. I also had another experience with na-semax (may have been amidate, I dont remember) and 30mg of tianeptine which ended in me trying to drink the irritation away)
I also had an experience with about 12mg of tramadol and na-selank which resulted in the same sort of mental/emotional discomfort and irritation.
That's all, if anyone has had similar experiences or may have an explanation, feel free to comment
What they were answering
Debonaire_Death · 1 points
Doesn't SEMAX have monoaminergic effects, as well? If you could go into detail on that it would be great.
I know Tianeptine does, including increasing dopamine.
I did a little snooping and found evidence that high dopamine levels can cause belligerence. Perhaps the tianeptine+SEMAX is causing a dopamine surplus.
u/MisterYouAreSoDumb · Ceretropic
Semax increases serotonin in the brain, but does not alter dopamine levels on its own. However, it does potentiate the dopamine release from other substances, like amphetamine. So combining Semax with Tianeptine could certainly increase dopamine levels more than just Tianeptine alone.