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Comment · Sat, May 30, 2015 · Ceretropic

Sources for delta sleep-inducing peptide (disp)?

Original post in this thread

Saussiche · 9 points

Anyone know if I can get my hands on this? If not, how much would it cost to get a sample manufactured (a la ceretropic)?

http://en.wikipedia.org/wiki/Delta_sleep-inducing_peptide

What they were answering

Saussiche · 1 points

would the reason for it be related to the in vivo N-terminal acetylation of the peptides in general? because I don't think it would be possible based on the sequence of disp (which isn't even naturally in human tissue?)

u/MisterYouAreSoDumb · Ceretropic

No, I was confused by the naming convention used in all the studies. They list the sequence as N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C, which is a different naming convention than I am used to. That is apparently a biochemistry naming convention, where they specify which is the N and C termini.

If we were to acetylate the N-terminus on this peptide, it would actually change the binding affinity, because it would change the shape of the peptide structure.

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