Comment · Mon, March 16, 2015 · Ceretropic
Ceretropic Stocks Tianeptine Sulphate
Original post in this thread
relbatnrut · 56 points
"There are a few problems with the common form of Tianeptine, the sodium salt. For one, it is very hygroscopic. This makes handling and storage a pain. More importantly, its short half life and pharmacodynamic properties make dosing required up to 3 times a day. This is where a more controlled release form comes into play.
Tianeptine hemisulfate monohydrate is an improved salt of Tianeptine. It is not hygroscopic, so handling the powder is a lot easier. Since it is not as readily absorbed and excreted from the body, the sulfate salt allows for a more controlled release of the Tianeptine over longer periods. Rather than having to dose three times, with rapid peak effects and rapidly falling effects, the sulfate salt allows for one dose to maintain plasma levels in the body much longer than the sodium salt. These improved characteristics make Tianeptine Sulfate a novel addition."
What they were answering
notthor214 · 9 points
Correct me if I'm wrong, but all the numbers for half life and peak concentration times seem to be for controlled release tablets incorporating the tianeptine sulphate. Is it actually absorbed slower on its own, or is it just that the improved physical characteristics make a controlled release form more practical to manufacture?
u/MisterYouAreSoDumb · Ceretropic
It definitely takes longer to reach effects, in our anecdotal trials. The fact that it is less hydroscopic, and less polar, makes the absorption a lot different than the sodium salt. The patent does get into polymer matrices used in tablets that can further augment the controlled release. However, the salt itself does have very different absorption characteristics on its own.