Comment · Fri, February 20, 2015 · Ceretropic
Anyone experimented with THT's CNTF fragment 147-150?
Original post in this thread
Debonaire_Death · 5 points
They posted it up awhile ago, and with all of the fuss over P21, it seems to have been swept under the rug.
Has anyone tried it? Is it a good value? I tried to check the price but THT.co is down.
I'm interested in trying another CTNF-related drug, thought it might be worth a shot if there are any good reports out there, but everyone seems busy with GTS-21.
What they were answering
redan-yadayada · -4 points
I can say your P21 doesn't work and you can say it does work. And we can do that all day? What's your problem with THT again?
u/MisterYouAreSoDumb · Ceretropic
I don't think you are getting my point. P21 has been proven to pass the BBB, and bind to CNTF in the brain, due to the modification made to the peptide. This was done at the Department of Neurochemistry at the New York State Institute for Basic Research in Developmental Disabilities. They go in detail as to why peptides incorporating DGGL are hard to target for drug delivery, because of their instability and low lipophillicity. They then test many peptide modifications to human CNTF, and assess which ones pass the BBB, and actually hit the receptors they are supposed to. This is not me saying I like P21, and you don't. That's irrelevant. I am saying that P21 actually passes the BBB, and acts on human CNTF, and straight DGGL does not. So selling DGGL as a powder is ridiculous, because it will never be useful to humans. It is a waste of people's money, and only being sold for the novelty. Whether you personally respond to P21 or not, there is no doubting that it actually does what it is supposed to do from a pharmacodynamic perspective. DGGL does not.
My problem with THT is that they are bringing out substances that are useless. I don't know if 18β-Glycyrrhetinic Acid Nanoparticles are useless, but I have my suspicions. However, I know DGGL powder is useless. I also know a lot about Cerebrolysin, and know that selling it as a powder is very suspicious. The only references to it existing as a powder, are on Chinese supplier sites, and recently created lookchem and chemicalbook entries, with no details filled out. That makes me suspicious. I am investigating the whole thing now, and pressing the Chinese suppliers to tell me how they are producing it, and the testing they are doing to ensure not only does it have the same peptide configuration as Ebewe's, but that it is safe from things like bacteria and prions. Because you sure as shit know people are going to be using it, research chemical or not. I care about the safety and efficacy of things being sold to the nootropics community. These are things I would expect a vendor to do BEFORE selling it to customers, not saying "not my problem."