Comment · Fri, February 6, 2015 · Ceretropic
Why do I feel so great after dosing icariin?
Original post in this thread
[deleted] · 15 points
I've noticed that, since starting occasional consumption of 500-750 mg of Icariin (40% from powdercity) - that I feel great! I feel confident, pro-social, my brain fog appears to lift and I can empathize with people easier. I originally got it for some intimate moments, but didn't think it would feel like an anti-depressant. To clarify, I've used this occasionally since two months ago, and whenever I use it, I get those effects. There appears to be tolerance if I use it everyday for a week though.
What is the mechanism? Does it increase dopamine/serotonin?
Other information:
I don't respond to MACA, aniracetam, pramiracetam is iffy, I respond to high-doses of piracetam, and noopept puts me in a weird headspace.
Here is what I found:
http://www.sciencedirect.com/science/article/pii/S0091305705003709
It is behind a paywall, so I've uploaded the paper here. http://www.docdroid.net/r373/1-s20-s0091305705003709-main.pdf.html
I may edit this with my summary of that paper.
Summary:
Introduction (this is study done on rats)
In depressed patients, the hypothalamic-pituitary-adrenal (HPA) axis is impaired. Corticotropin releasing factor (CRF) acts to regulate the HPA. These scient…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
PDE5 inhibitor, increases nitric oxide, and mimics testosterone. Sounds like it'll get your sexual motor running. Have you had your basal testosterone levels checked?