Comment · Wed, December 10, 2014 · Ceretropic
What they were answering
[deleted] · 1 points
No one knows. Long term nicotine use in the absense of any MAOI is new territory. It's turning out to be less addictive (we think) but there is currently few studies as to why.
u/MisterYouAreSoDumb · Ceretropic
No, it's MAO-A. See the study above.
Comment · Tue, December 9, 2014 · 22 pts
Not with that attitude! Now we just need to put some MAOIs in the E-cig liquid, and they will be addicted again in no time.
Comment · Tue, December 9, 2014 · 8 pts
Ohh I know. It just also makes it more addictive.
Comment · Tue, December 9, 2014 · 3 pts
I use it, if that means anything. Haha
Comment · Wed, December 10, 2014 · 1 pts
No, just the gum. Vaporizing is a bit too strong for my tastes.
Comment · Wed, December 10, 2014 · 4 pts
It depends on the MAOI you use.
Comment · Wed, December 10, 2014 · 1 pts
MAO-A [Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats.](http://www.ncbi.nlm.nih.gov/pubmed/17229101)
Nicotine up-regulates nicotinic ACh receptors, but also desensitizes them. It's more complex than just up/down-regulation. Acutely, caffeine lowers GABAergic neurotransmission. [Inhibitory effect of caffeine on GABA-ac
Replying to silverhydra · I noticed a nice little bit of ocular contracton (the area beside the eyes on the outside) when the gum is in my mouth, and then increased focus thereafter; haven't noticed anythin…
The notoriety is due to the fact that most people smoke tobacco to get it. Tobacco smoke contains harman and norharman, which are monoamine oxidase inhibitors. This increases the extracellular dopamine, serotonin, and no
We are going to come out with a Cytisine sublingual solution shortly. I usually chew nicotine gum in the morning. However, Cytisine feels more effective to me, and seems a bit smoother. Also, Cytisine has been shown to b
Replying to thelurkingdead · >Regardless, to be a nootropic, a substance has to be non-toxic. Says who? This is a great example of the type of uneducated armchair Pharmacology that goes on in this sub. The LD…
Call me an uneducated armchair pharmacologist all you want, but you are wrong! To be considered a nootropic, a substance must: >Exhibit few side effects and extremely low toxicity, while lacking the pharmacology of typ
Replying to FW900 · EDIT: This is very unlikely as ND (where OP obtained all his nootropics) tests each batch and provides full transparency of the results. The same cannot be said for most supplement…
We have an ISO certified lab in-house, and test for contaminants in every single batch. We have a UPLC-MS, along with tons of other equipment that we use to test every single batch of material that comes into our facilit
Don't smoke anything! It's a barbaric way to ingest molecules. It's 2014! Vaporize or use the gum. Nicotine is a very effective cognitive enhancer. It is relatively safe when used appropriately. I would put it in a simi