Comment · Tue, November 18, 2014 · Ceretropic
Experience Report: P21 is pretty alright.
Original post in this thread
ffishphone · 30 points
I can't put a finger on it, but after injecting 2mg SID for a week something is happening. I've cycled through a plethora of nootropics - the classic common varietals, obscure/exotic flavors old and new, and many of the pharmaceuticals that could be construed as such - but this is unique. Granted I've never tried Cerebrolysin given my aversion to IM injection and the volume necessary to achieve significant effects, but P21 is relatively unparalleled in my experience base thus far. Subjectively the closest comparable compound I've sampled is Semax, but P21 is more akin to my lofty, unfulfilled expectations of NSI-189 if anything. There's a lucid clarity to thought processes and augmentation of cognitive stamina resembling Semax, but P21 seems to significantly enhance my memory and linguistic abilities while incorporating a subtle, gradual mood lift as time has progressed. It's also less physically stimulating than Semax. If I had to try and nail it down, a low dose cocktail of Semax, Hydergine, and Oxiracetam is the most similar state I've achieved subjectively, but that's still a fairly poor approximation. P21 has maintained its effects throughout the day, has progressively incr…
What they were answering
ChristianHunter · 1 points
"P21 has an adamantane moiety off the N-terminus"...right, of course, but but JIC we've got some total idiots trying to follow along (def not me though), maybe it'd be helpful for them if you would rephrase in layman's terms?
And if you were using layman's terms, please add two additional vials of P21 to my card and ship ASAP!
u/MisterYouAreSoDumb · Ceretropic
The N-terminus refers to the start of a peptide that is terminated by an amine group. So when you look at a peptide sequence, it goes from N to C termini, left to right. The sequence itself is a list of amino acids that make up the polypeptide. They are bound together with peptide bonds, which are not as strong as covalent bonds. That is why peptides are not very orally bioavailable, as enzymes can rip apart those peptide bonds quickly.
Adamantane is a cycloalkane molecule that is used in P21 to attached to the N-terminus of the peptide sequence, and protect it from ezymatic degradation. That is what makes P21 stable in plasma long enough to pass the blood brain barrier, and exert its effects. It's still not orally bioavailable, though.