Comment · Sat, November 8, 2014 · Ceretropic
Why does Tianeptine stop working
Original post in this thread
Dakman1 · 0 points
I had a great two weeks when starting and felt like I think I should feel but don't. Now no matter how high I dose or how often, I get no effect. A one week break and restart has also brought no results. It seems the only things I respond to with any efficacy are phenibut at recreational doses or cannabis.
What they were answering
NotHyplon · 3 points
I have a messed up GI system which basically requires constant opiates to work properly. Usually this is loperimide but also codeine for when pain flares up. (in the past morphine, DHC, tramadol as well)
Needless to say having had multiple different opiates Tianeptine does absolutely nothing opiate wise in the GI system. Whatever affinity it must have for mu-opiod receptors must be really poor because it does sod all.
I think people are seeing the mouse studies and blowing them out of proportion thinking tianeptine is some unscheduled opioid/opiate that can give a similar recreational effect to others in that class.
Also there seems to be a massive misunderstanding that the body's opiate receptors are just there to kill pain/get you high, what the mouse study's i saw for tianeptine was basically saying that the opioid system may have a larger impact on things like stress, anxiety and depression then previously thought not that tianeptine is some opiate that will send you nodding off.
Once again your right in that this is going to get stuff scheduled pretty rapidly especially once someone does something stupid in a polydrug situation where one of which is tianeptine. There is some serious chatter at the moment in the UK about having a whitelist of psychoactive substances because of the RC scene which could kill all nootropics dead because people can't be responsible.
u/MisterYouAreSoDumb · Ceretropic
It is very poor. It has 3 times less affinity for the μ-opioid receptor than codeine, and 50 times less affinity than 7-hydroxymitragynine in kratom. You need high dosages for it to come anywhere near a real opioid, and then you get the bad side effects with it. It is not a recreational drug, and people trying to use it as one are idiots. It is going to eventually deprive those people benefiting from the therapeutic effects. There are so many people with depression benefiting from tianeptine. It would be a damn shame if they cannot get it anymore, because some morons don't know how to get real opioids.