What is the relationship between Ceretropic and Nootropics Depot?

Are Increased Gaba Receptors By Chronic Caffeine Intake A Good Thing?

Nicotine up-regulates nicotinic ACh receptors, but also desensitizes them. It's more complex than just up/down-regulation. Acutely, caffeine lowers GABAergic neurotransmission. [Inhibitory effect of caffeine on GABA-ac

Nicotine and cognitive decline

Don't smoke anything! It's a barbaric way to ingest molecules. It's 2014! Vaporize or use the gum. Nicotine is a very effective cognitive enhancer. It is relatively safe when used appropriately. I would put it in a simi

Smart drugs: A dose of intelligence

Replying to BigYellowLemon · I have never read an article about nootropics that left me with anything but anger and annoyance. The only "nootropics" I ever hear about are methylphenidate, modafinil, caffeine…

It's because the people that actually have something to say don't want to talk, and the people that want to talk have nothing to say. Did the world need another article about amphetamine, methylphenidate, and modafinil?

How do the nootropic effects of caffeine change with tolerance?

Replying to satoshi_btc · What about nicotine? It is far more useful than caffeine.

I like nicotine too. It certainly can maintain cognitive effects when dosages are kept reasonable. I would not say it is far more useful than caffeine, though. Perhaps for you. No substance on the planet has been more pr

Sunifiram and nicotine

Sunifiram seems to potentiate ACh agonists, and other stimulants. So be careful mixing them. Someone on Longecity already went to the hospital because he mixed high doses of caffeine with high doses of sunifiram. Sunifi

Bacopa Monnieri: The Most Impressive Natural Nootropic?

Replying to AdAstraPer5-HT2Ar · Exercise boosts the fuck out of me much more than caffeine or nicotine so there's that. I don't think that there is anything else in my stack that would counter it. Bacopa's pharma…

I think the most likely explanation is the simple one. Bacopa up-regulates tryptophan hydroxylase, which increases 5-HTP production, which competes with L-DOPA for the aromatic L-amino acid decarboxylase enzyme, which lo