Comment · Fri, September 19, 2014 · Ceretropic
Cycling Semax from Ceretropic
Original post in this thread
[deleted] · 0 points
Hi,
I'm just wondering if there is any reason why cycling Semax is recommended? I have been taking it for two weeks and I do like the effects. It is my "go to" nootropic and replaced everything in my stack (I was tired of having to take 3-4 different substances).
I'm planning on taking Semax for 4 months (until I run out because I don't want to waste any and it will "expire by then") and then do a two month cycle of Noopept and fasoracetam (to curb the irritability). Go back on Semax then.
Will it downregulate anything? If I take the weekend off, is it enough? Any papers on why we should cycle? Is Tkb downregulation permanent?
I take 10mg a day of Noopept and 500mcg of Semax SQ.
My objective are long term neuroplasticity and mental "youth".
What they were answering
[deleted] · 3 points
No actually the effects seem to be cumulative. I could tell it really was assisting me after 3-4 days and both my N-Back and working memory have improved ever since.
There was some post on exposure to BDNF and NGF causing Tkb (receptors) downregulation. I don't know if it the nootropics community is being ticklish or bro science and the paper I've seen was a little sketchy. Yet, some users have been taking NGF all their life and were fine (including the lady who discovered it! She took it through her eyes nonetheless!)
When I run out, I will order more. My finances are pretty good :-)
* Edit: typos
u/MisterYouAreSoDumb · Ceretropic
The TrkB down-regulation was somewhat speculative. There is no evidence that Semax causes it. However, elevated BDNF can cause it, and Semax does elevate BDNF. So it was a jump to causation with the mechanisms. But we do not know if it does or not.