Comment · Mon, September 8, 2014 · Ceretropic
Accuracy of Genetic Genie methylation analysis
Original post in this thread
luketheduke0 · 7 points
I recently learned of the 23andme genome interpretation service offered at www.geneticgenie.org. The website states:
> This website looks at your methylation genetics just by reading your 23andMe raw data. After you receive your results from 23andMe, click on the Methylation Analysis link, follow the simple instructions, and you’ll see some of your methylation-related genetic polymorphisms.
>
> Studies have shown that DNA Methylation can be altered with vitamins such as B12, Folate, SAMe, and other methyl donors.
If it's true, it would allow for optimized supplementation to correct genetic abnormalities. I've already ordered a kit from 23andme and am awaiting its arrival, but I wanted to get the opinion of the Nootropic community. Might this work? Or is it just pseudoscience?
What they were answering
NinetiesGuy · 2 points
Here's my list from Genetic Genie
If it matters, I'm troubleshooting the cause of what will probably end up being diagnosed as idiopathic hypersomnia. That diagnosis is not very helpful, especially since the usual treatment is modafinil, which I'm a non-responder for.
u/MisterYouAreSoDumb · Ceretropic
It looks like you have trouble breaking down neurotransmitters after they are used. So most likely your DA, NE, and 5-HT receptors are down-regulated, due to the higher than normal amounts of their ligands. You might also have slightly higher levels of homocysteine than normal, due to being a slow metabolizer. However, those mutations are not homozygous.
So you might want to supplement with some folate, B6, and B12. Then you should take some things to up-regulate your DA, NE, and 5-HT receptors. Saint John's Wort can help up-regulate serotonin receptors. CDP-choline and uridine can help up-regulate dopamine receptors, and Benadryl can up-regulate beta adrenic receptors. That last one might not be the best long term, but I cannot think of anything else right now.