Comment · Mon, September 8, 2014 · Ceretropic
Accuracy of Genetic Genie methylation analysis
Original post in this thread
luketheduke0 · 7 points
I recently learned of the 23andme genome interpretation service offered at www.geneticgenie.org. The website states:
> This website looks at your methylation genetics just by reading your 23andMe raw data. After you receive your results from 23andMe, click on the Methylation Analysis link, follow the simple instructions, and you’ll see some of your methylation-related genetic polymorphisms.
>
> Studies have shown that DNA Methylation can be altered with vitamins such as B12, Folate, SAMe, and other methyl donors.
If it's true, it would allow for optimized supplementation to correct genetic abnormalities. I've already ordered a kit from 23andme and am awaiting its arrival, but I wanted to get the opinion of the Nootropic community. Might this work? Or is it just pseudoscience?
What they were answering
NinetiesGuy · 2 points
Do you know of any flow-chart type references that take into account all mutations you might have and builds a supplementation strategy based on that? Or do you need to wade through all the sources and put it all together manually?
I admittedly have no knowledge about this stuff other than what I've read in the last couple of days, but it looks like it's not as clear-cut as "if you have X, do Y" because some mutations cancel out others and the combinations seem important.
Also, in order to simplify things, is it correct to disregard any mutations or combinations that aren't mentioned explicitly? For example, I don't see anything for COMT H262H (+/+) and VDR Taq (+/+).
u/MisterYouAreSoDumb · Ceretropic
You kind of have to do it manually. That is for two reasons. One, nobody has made an all-in-one table/tool. And two, you want to verify the claims by doing your own research. It gets very complicated with multiple heterozygous and homozygous mutations, as they all affect each other.
Where are your mutations, and are they homozygous or heterozygous?