Comment · Sun, February 23, 2014 · Ceretropic
Methylphenidate Neurotoxicity?
Original post in this thread
nstat41 · 3 points
Does anybody have a link to / know anything about / if Methylphenidate has neurotoxic effects on the brain after continuous administration, especially as it relates to serotonin transporters? I am currently prescribed to take Amphetamine for ADHD, but am begin to notice some serotonin neurotoxicity-like effects, ie heightened anxiety when not on the medication. Is methylphenidate healthier?
What they were answering
iGotMyPhdInThis · 3 points
I think you linked it to me actually bud.
Is this it?
Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for the symptomatic treatment of ADHD and narcolepsy; although lately, there has been an increased incidence of its use in individuals not meeting the criteria for these disorders. MPH has also been misused as a “cognitive enhancer” and as an alternative to other psychostimulants. Here, we investigate whether chronic or acute administration of MPH in mice at either 1 mg/kg or 10 mg/kg, affects cell number and gene expression in the basal ganglia.
Conclusion
Collectively, our results suggest that chronic MPH usage in mice at doses spanning the therapeutic range in humans, especially at prolonged higher doses, has long-term neurodegenerative consequences.
u/MisterYouAreSoDumb · Ceretropic
Yes, that is the one. Thanks for finding it!