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Comment · Wed, February 19, 2014 · Ceretropic

Methylphenidate Neurotoxicity?

Original post in this thread

nstat41 · 3 points

Does anybody have a link to / know anything about / if Methylphenidate has neurotoxic effects on the brain after continuous administration, especially as it relates to serotonin transporters? I am currently prescribed to take Amphetamine for ADHD, but am begin to notice some serotonin neurotoxicity-like effects, ie heightened anxiety when not on the medication. Is methylphenidate healthier?

What they were answering

shrillthrill · 5 points

Still well tolerated after almost 15 years of varied use here. I've not read anything that would dissuade me from continuing to get a prescription for it.

Neuropharmacological mechanisms underlying the neuroprotective effects of methylphenidate.

Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro.

Methylphenidate enhances neural stem cell differentiation.

u/MisterYouAreSoDumb · Ceretropic

Remember that paper I linked you showing long-term methylphenidate use caused loss of dopamine terminals? I'll have to try and find it again.

It is a lot safer than amphetamines, for sure.

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