Comment · Fri, January 24, 2014
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
What they were answering
commentguy123 · 18 points
Your position on SSRIs is far too generous. Sexual dysfunction, emotional blunting, apathy, weight gain, birth defects, publication bias, evergreening. Plus you've got to be addicted before it is considered to be working. Get real.
Meanwhile, tianeptine (which reduces synaptic serotonin and modulates glutamate) has been shown to be as effective as paxil for treating major depression with fewer side effects. Did I mention it works immediately? Tianeptine will never be FDA approved because it is off patent so no one will pay for the trials. Doctors can't prescribe it despite being a better first line treatment. That's a serious societal problem.
SSRIs are a pharmacological deadend and should only be prescribed in conjunction with therapy and a well-defined discontinuation target. Instead, physicians consider them relatively benign, hand them out without much thought, and consider you "cured" once you pass a Beck inventory even though you're now addicted to a pill with unclear effects on cognition for maybe forever. Bullshit. Bad medicine go home.
u/MisterYouAreSoDumb
Tianeptine is a great molecule. I took some earlier. Most of our customers that have used it, love it. It is a shame that lack of patents are the only thing preventing doctors from prescribing it. However, at least it is unscheduled.