Comment · Mon, December 30, 2013 · Ceretropic
Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?
Original post in this thread
alan2102 · 21 points
"Both in vitro and in vivo, melatonin was effective to prevent
oxidative stress/nitrosative stress-induced mitochondrial
dysfunction seen in experimental models of AD, PD and HD.
These effects are seen at doses 2-3 orders of magnitude higher
than those required to affect sleep and circadian rhythms....
clinical trials employing melatonin in the range of
50-100mg/day are needed to assess its therapeutic validity in
neurodegenerative disorders."
Or, for prevention in (presumably) healthy people, maybe just 5-10 mg/day?
Just a crazy unjustified wild-ass guess.
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http://www.ncbi.nlm.nih.gov/pubmed/22391273
Horm Behav. 2012 Feb 25.
Melatonin and mitochondrial dysfunction in the central nervous
system.
Cardinali DP, Pagano ES, Scacchi Bernasconi PA, Reynoso R,
Scacchi P.
Cell death and survival are critical events for
neurodegeneration, mitochondria being increasingly seen as
important determinants of both. Mitochondrial dysfunction is
considered a major causative factor in Alzheimer's disease
(AD), Parkinson's disease (PD) and Huntington's disease (HD).
Increased free radical generation, enhanced mitochondrial
inducible nitric oxide (NO) synthase activity a…
What they were answering
machete234 · 1 points
So its probablya good idea to take 1mg every night if you have sleep problems or not?
Or is there some kind of downside to have less oxidative stress? Making your immune system lazy or something?
u/MisterYouAreSoDumb · Ceretropic
It really depends on your body. Hopefully your body is making enough melatonin on its own. However, if it is not, .5mg-1mg is good for daily use.
I would say supplement it at the same time every night 30min before you go to bed, then supplement vitamin D when you wake up. This will get your circadian rhythm in sync.