Comment · Sun, December 29, 2013
Can someone recommend a stack for depression, social anxiety, concentration, motivation?
Original post in this thread
remedydoc · 10 points
Thanks.
Edit: Would like to restrict to supplements, maybe racetams or adrafinil. Definitely nothing illegal.
What they were answering
remedydoc · 1 points
Thanks for the info. I just looked into tianeptine and it said it is a SSRE. How would increasing the reuptake of serotonin, thereby decreasing synaptic concentrations, help depression?
I'm on an SSRI/SNRI now and it helps to a degree. Wouldn't this counteract that?
u/MisterYouAreSoDumb
It's an SSRE in high doses, in very specific brain regions. That is not its main mechanism, though. It mainly increases dopamine levels and protects from stress-induced neuroplastic remodeling in the hippocampus. It also increases BDNF in various brain regions, allowing the brain to repair neuronal connections. On top of that, it helps modulate the glutamate system, and inhibit the pathological stress-induced changes in glutamatergic neurotransmission in the hippocampus and amygdala.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902200/
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Also, studies have shown that combining tianeptine with SSRIs proves to be more effective in depressive patients than either one alone. So they do not cancel each other out as some people will tell you online.