Comment · Sun, December 8, 2013
MDMA harm reduction - order of supplements
Original post in this thread
zivilkannibale · 19 points
Hi all,
after researching about MDMA harm reduction, with the main source being /u/MisterYouAreSoDumb 's thread (http://www.reddit.com/r/DrugNerds/comments/15m9sf/mdma_supplementation/), I managed to get hold of the essential supplements. This is certainly no easy endeavor if you don't happen to live in the US. Had to import half of these supplements through customs. Such a hassle.
I have
* 2 litres of grapefruit juice
* Vitamin C capsules, with 750mg VitC and 100mg grape seed extract
* Magnesium glycinate pills, with 200mg elemental Mg
* Na-R-ALA capsules, with 100mg R-ALA
and for the morning after
* 5HTP pills with 100mg 5HTP (time release)
Now I was wondering about the order of supplementation. To keep it simple, I was planning on putting one of each into three baggies, and then pull out a baggie a time in the middle of the club and swallow all the pills at once. I dont want to worry more about taking my supps at the right moment than actually partying.
So the schedule is
* 6 hours before: Mg
* 1 hour before: VitC, Mg, Na-R-ALA
* take MDMA
* 2 hours in, another VitC, Mg, Na-R-ALa
* 3 hours later, the last baggie
**Do these supplements have any synergy or contraindicant…
What they were answering
gonzobon · 1 points
Wow the 5HTP thing is super true. I took it with my first roll years ago and crashed hard for a month. Boy was I stressed
u/MisterYouAreSoDumb
5-HTP should be taken AFTER the roll, and always with EGCG. MDMA will reduce your tryptophan hydroxylase enzyme levels by up to 90% in some cases. That is the enzyme that turns dietary tryptophan into 5-HTP. If you do not supplement 5-HTP in the 3-5 days following the roll, then you will get depressive symptoms a few days after you roll is over, as your body is physically incapable of producing the necessary serotonin your system needs. Pair that with the down-regulation of the 5-HT receptors themselves, and you can have a bad time.