Comment · Wed, November 6, 2013 · Ceretropic

Coluracetam, IDRA-21, and PRL-8-53.

Original post in this thread

lynxon · 9 points

Anyone want to speculate on these two recently available compound's (IDRA-21 and PRL-8-53) interactions with Coluracetam?

Does anyone think they would be safe or unsafe to experiment with (ideally low dose) combinations of these three, or a combination of two out of the three?

What they were answering

probablytoomuch · 1 points

I've experienced the same reaction with combinations of Coluracetam and Unifiram. It's a peculiar and specific feeling, hot but not hot, fever but no fever. I find it notable because my hands/skin are generally cold to the touch. I've heard some AMPAkines were used back in the day to increase cold resistance- is it possible that strong positive modulation of AMPA receptors can result in thermogenic effects?

u/MisterYouAreSoDumb · Ceretropic

It's possible. It definitely seems to be happening with IDRA-21. I have not tried unifiram yet, so I can't tell if it leads to similar effects. I've never noticed it on coluracetam.

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