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Comment · Thu, October 31, 2013 · Ceretropic

Memantine's effect on drug tolerance prevention / anecdotes

Original post in this thread

drejp · 18 points

I would love to hear some anecdotes about Memantine and its NMDA-antagonistic properties. Did it benefit you in preventing/reducing tolerance to drugs/nootropics? If so, what drugs?

I'm mainly looking in to this compound for reducing tolerance to Phenibut (which i've read some success story about), but also alcohol and other GABAergic drugs.

For the side effects of Memantine, i'm a bit worried of the brain fog phase which I've read could go on for a couple of weeks. Cant really afford being too zombified at work where I need to be focused. Have you experienced any brain fog/cognitive decline and if so, did it fade later on in the treatment?

Every answer is much appreciated.

What they were answering

synergystudent · 1 points

Would memantine also reduce tolerance to nicotine and caffeine or only amphetamines?

u/MisterYouAreSoDumb · Ceretropic

It might help nicotine tolerance, as it is a nicotinic acetylcholine receptor antagonist. That will lead to up-regulation of the receptors. However, I am not sure if it will reverse receptor desensitization. It also might help reverse caffeine tolerance. But that is pretty quick to subside as it is.

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