Comment · Fri, September 6, 2013 · Ceretropic
Is it necessary to maintain a piracetam blood serum level?
Original post in this thread
Damderiam · 20 points
With a half life of 4-5 hours it would require measuring and taking exact doses 3-4 times a day, and that's just not feasible all the time. However, there are plenty of medicines that continue to act, indirectly, after they've been eliminated. Am I getting any effect at all by taking it prior to bedtime, or would a morning dose be necessary as well? Since we don't know exactly how piracetam works I'll have to go by anecdotes and experimental evidence, but it's better than winging it. I figure it may, for example, increase the efficiency of sleep, or have lingering effects.
What they were answering
AgentLiquid · 2 points
I found a little bit of information here. See section 2.1.3:
http://www.imaginarymap.com/Piracetam%20and%20Other%20Nootropics.pdf
It seems like the relative CSF concentration is 10/180 = 5.5%! Very similar to that of oxiracetam.
u/MisterYouAreSoDumb · Ceretropic
Good find! There must be some peripheral mechanism that plays a role in oxiracetam's higher potency. I have a feeling it's adrenal mediated.
Ohh, and fuck all the sites online spouting off BS about these molecules! It makes it hard to figure this shit out when people are espousing incorrect information as fact. I see no evidence for "easily" crossing the blood brain barrier, nor do I see any evidence that oxiracetam penetrates better. In fact, we are seeing it penetrates slightly worse.
This data is actually making me rethink some of the mechansims for the racetams. Perhaps the adrenals play a much larger role than we thought.