Comment · Fri, September 6, 2013 · Ceretropic
Is it necessary to maintain a piracetam blood serum level?
Original post in this thread
Damderiam · 20 points
With a half life of 4-5 hours it would require measuring and taking exact doses 3-4 times a day, and that's just not feasible all the time. However, there are plenty of medicines that continue to act, indirectly, after they've been eliminated. Am I getting any effect at all by taking it prior to bedtime, or would a morning dose be necessary as well? Since we don't know exactly how piracetam works I'll have to go by anecdotes and experimental evidence, but it's better than winging it. I figure it may, for example, increase the efficiency of sleep, or have lingering effects.
What they were answering
chyckun · 2 points
How can you increase the bioavailability of it? Is this possible? Or, how can you increase absorption so that it isn't mostly excreted?
u/MisterYouAreSoDumb · Ceretropic
Use oxiracetam. That's the same molecule as piracetam, with an extra hydroxy group. It's half life is 8 hours. The only way to extend the half life is to impair kidney function. You don't really want to do that.