Comment · Mon, August 19, 2013
Can you develop tolerance to antihistamines ?
Original post in this thread
g0rth · 18 points
So, the allergy season has once again struck upon me and was wondering if it is preferable to switch between various antihistamines to have them fully effective. My favorite one has always been fexofenadine, but I found it loose its effectiveness over longer period of use. Last year, I alternated between fexo and diphenhydramine, but the adverse effects of DPH weren't that welcome.
So do you guys know if there's such a thing as tolerance to antihistamines of was it just in my head ?
What they were answering
blackfox026 · 3 points
Does the brain up-regulate histamine receptors during extended use, resulting in a noticeable withdrawal effect?
u/MisterYouAreSoDumb
I would imagine so. I would not be able to give you an anecdote, though. The longest I've gone without antihistamines in the last 15 years is about 24 hours. Any longer and I would literally want to die. Every part of my body would itch and become inflamed. My eyes, the palms of my hand, in between my toes, everything! Then my airway would most likely close up.
I do NOT go off my antihistamines.