Comment · Wed, August 14, 2013 · Ceretropic
What they were answering
deh707 · 2 points
Interesting. How about something even more common... such as good ol' caffeine?
u/MisterYouAreSoDumb · Ceretropic
Caffeine is mostly metabolized by CYP1A2, but has some minor CYP3A4 activity. It probably won't make too much of a difference.
Comment · Wed, August 14, 2013 · 5 pts
Not at all. Most of the racetams are not metabolized by CYP3A4. The only one that I know of that is a substrate for CYP3A4 is nefiracetam.
Comment · Wed, August 14, 2013 · 5 pts
That was placebo. Piracetam is not metabolized by CYP3A4, or at all. Almost all of it is excreted unchanged in urine.
Comment · Thu, August 15, 2013 · 7 pts
Coffee filters.
The time has finally come to launch our nootropics site! For those of you that don’t know, a fellow Redditor, /u/guacamolium, approached me a while back. He was interested in starting a nootropics vendor, and thought par
Replying to amirrorbehind · One of the contributing factors is the cult of celebrity. I need not explain who nor am I criticizing, but once a respected member of our community turned into a research chemical…
Yep, my fault guys. I'll just stop posting, and things will get better. It's all on me... You can all go back to caffeine/L-theanine, long winded modafinil, and "does piracetam work" posts. No need to advance the communi
6mg of melatonin is too much. I take .5-1mg. Melatonin has been shown to be much more effective at lower doses. Lower your dose and see how that works. 6mg would mean a very hard time waking up, and hours of foggyness in
First off, you are not really going at this from a nootropic standpoint. You are heavily reliant on multiple stimulants. You are hitting your adenosine receptors with the caffeine. You are hitting the histamine system wi
It's really very complicated. There is competitive binding affinities you have to consider. Plus, downstream mechanisms that may alter the effects. Not to mention the varying level of responses between different people.
Replying to BigYellowLemon · I have never read an article about nootropics that left me with anything but anger and annoyance. The only "nootropics" I ever hear about are methylphenidate, modafinil, caffeine…
It's because the people that actually have something to say don't want to talk, and the people that want to talk have nothing to say. Did the world need another article about amphetamine, methylphenidate, and modafinil?