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Comment · Tue, April 23, 2013 · Ceretropic

What are the causes of Noopept short-term memory loss?

What they were answering

Direct reply to the original post in this thread.

u/MisterYouAreSoDumb · Ceretropic

I have a feeling it has something to do with noopept's lowering of spontaneous and stimulated glutamate release. I suspect that effect arises from it's affinity for the glycine site of the NMDAR, or possibly non-NMDA glutamate receptors.

http://ge.tt/8V7XTse/v/0?c

>Noopept significantly decreased the level of
both spontaneous and stimulated glutamate release.
The extent of this decrease depended on the peptide
concentration. It was significantly higher at a concen-
tration of 10 –6 M than at 10 –5 M. The observed decrease
in the peptide effect at its higher concentration suggests
a bell-shaped curve of the dose-effect relationship,
which is characteristic of a number of peptides, includ-
ing Noopept

This makes sense, since I get this effect much more noticeably the higher I go above a 15mg dose. The bell shaped response curve is pretty significant with noopept.

http://ge.tt/6QK6Vse/v/0?c

That study showed that the membrane potential was altered due to blockage of K^+ channels instead of the NMDA mediated Ca^2+ channels.

More research needs to be done here.

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