Acetylcholinesterase Inhibitors and Bedtime

I'd say stay away from AChE inhibitors at bed time.

http://www.pnas.org/content/101/7/2140.full

This framework assumes that, whereas acquisition of declarative information during the wake state needs the higher cholinergic tone, the long-term storage and integration of the materials into neocortical networks require a period of release from cholinergic suppression of feedback transmission in the hippocampus.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534696/

ACh inhibits feedback loops within the hippocampus and between the hippocampus and neocortex. Thus, high cholinergic activity during wakefulness allows encoding of new declarative memories, whereas low cholinergic activity during SWS supports the spontaneous replay of newly acquired information in the hippocampus.

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http://www.sciencedirect.com/science/article/pii/S1364661399013650

>During active waking, cholinergic
suppression of excitatory feedback reduces this influence
to a level that allows normal retrieval, but prevents distortion
of the incoming sensory information being
encoded. Indeed, blockade of this suppression by muscarinic
receptor antagonists can cause hallucinations.
During quiet waking and slow-wave sleep, lower levels of
acetylcholine allow these excitatory feedback connections to
have a stronger influence. This would allow the associations
encoded within the CA3 region of the hippocampus to be
re-activated, allowing further strengthening of these associations
in CA3, and allowing formation of additional associative
links for memory in CA3, CA1, entorhinal cortex
and even association neocortex.

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So it would seem that increase ACh activity during wakefulness promotes learning, while low ACh activity during slow wave sleep promotes long-term retention of that information. Interestingly enough, high ACh activity during REM sleep prevents distortion of the sensory information.