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Caffeine + L-Theanine sublingual solution recipe?

Replying to FosteredWill · Haha! I thought for some weird reason maybe it was cost-effective, and was distracted from the sarcasm by the Fiji vs. others. Seemed strange to me. The idea for me of vodka was …

Just keep in mind that any molecule that is subject to hydrolysis will degrade in water. Since most of the vodka is water, that means it will break down the molecule. Noopept is one of those molecules.

Can someone recommend a stack for depression, social anxiety, concentration, motivation?

Replying to nuxeon · Hey, this is kind of an off topic question but for the sublingual solution, would it be save to assume that it would be unwise to order this if it is going to sit in a mailbox in -…

Hmmm, that's pretty cold. Let me talk to Jason about it.

I now have about a gram and a half of NSI-189, What's a good way to map any potential benefit?

Replying to EnLilaSko · http://en.wikipedia.org/wiki/Hamilton_Rating_Scale_for_Depression http://img.medscape.com/fullsize/migrated/447/735/dn447735.fig.gif There are a few, pretty much just to answer q…

Ohh, ok. I've done that one. It's super subjective. I was hoping there was a more scientific way to measure it.

Caffeine + L-Theanine sublingual solution recipe?

Replying to FosteredWill · > San Pellegrino This is a bit old of a post, but man, are you just joking around when you say stay away from Fiji? Also, would it be damaging to most noots to use a weaker vodka…

Haha, I was being sarcastic! We certainly do not use any of those waters in our solutions. Vodka can work for the substances that are soluble in alcohol. Although in ingesting alcohol with your noots is kind of counterproductive.

I now have about a gram and a half of NSI-189, What's a good way to map any potential benefit?

Replying to EnLilaSko · http://www.quantified-mind.com/ Dual-n-back (exists on the page) Depression score Do it blinded etc

How does the depression score work?

Scientist claims nicotine is the best cognition enhancer

Replying to silverhydra · What led you to think BBB permeability rather than another possible cause like intestinal absorption rates or differences in the mechanism of action?

The fact that neither sublingual nor oral administration made a difference, and the fact that the supplements in question worked on completely different monoamine systems.

Scientist claims nicotine is the best cognition enhancer

Replying to silverhydra · Since they used patches, I would imagine the C*max* at any single time for nicotine would be too small for cognitive effects.

For the nicotine, probably. However, they also said that none of the other supplements they have tried have worked. I've met a few people like that over the years. Different drugs working on completely different systems had little to no effect. The only thing I could think of was…

Nature's Way supplements: what's the consensus?

I've used Eclectic Institute's rhodiola, with good effect. I am now using Life Extension. It seems to be just as effective so far. I would personally not use Nature's Way if I had the choice.

Scientist claims nicotine is the best cognition enhancer

Replying to hackinthebochs · Nothing that was noticeable enough to warrant continued use (I use creatine for bodybuilding purposes). I'm not a consistent caffeine user but I've never noticed any benefit of tha…

I wonder if it has something to do with your blood brain barrier permeability?

Nootropics Depot Adrafinil

I made that comment a while back, when there was a lot of reports of fake adrafinil. I have not heard any in a while, so hopefully that means vendors are actually selling legitimate product now. I know we are, and I assume Nootropics Depot is as well.

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to machete234 · I allready have vitamin d at 5000 iu, which is a bit much. Its not stimulating at all but maybe it just doesnt feel that way.

It's not really stimulating, so much as it regulates your circadian rhythm and improves mood.

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to machete234 · So its probablya good idea to take 1mg every night if you have sleep problems or not? Or is there some kind of downside to have less oxidative stress? Making your immune system la…

It really depends on your body. Hopefully your body is making enough melatonin on its own. However, if it is not, .5mg-1mg is good for daily use. I would say supplement it at the same time every night 30min before you go to bed, then supplement vitamin D when you wake up. This wi…

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to shydominantdave · Now that I think about it, it may make the most sense to take it in the morning. Taking it when levels are low and your body is not producing it should cause for less down-regulati…

Well that would make you pretty tired throughout the day. It might be best for antioxidant purposes, but it would mess with your circadian rhythm pretty bad. It would also mess with your vitamin D levels, since melatonin and vitamin D disrupt each others actions. This would lead…

The antidepressants associated with greater risks of hepatotoxicity are ... , tianeptine, ... .

Replying to xsiv1 · After a family tragedy, I experienced severe insomnia. That was good my primary symptom. Turned out it was a major depressive episode. Long story short, went through all the ssri's…

It could work. Tianeptine has been combined with Paxil before with good effect. However, you should speak to your doctor about it.

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to shydominantdave · 1. Wouldn't it not be advisable to take a sleep-inducing hormone twice a day? (unless it is like 9PM and 12PM, or you wake up to take it) 2. Not sure if this is talked about, but …

Both of those are valid concerns. The study was attempting to measure antioxidant ability, and did not take into account changes in circadian rhythm or down-regulation. This is why they are attempting to create melatonin analogs that have the same or better antioxidant abilities,…

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to timevast · How would you determine dosage?

No idea. I need to read more.

Yeast production of nicotinamide riboside - Google Patents

Replying to sd002002 · >It would be a cool test to use this strain. If you actual do decide to test the NR producing yeast, I've been doing some reading, and the strain that I pointed you to may not be …

Interesting. I admittedly do not know as much as I would like about yeast reproduction. I should really look into it, as yeast is a pretty big part of the beer.

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to iGotMyPhdInThis · Chemistry is crazy. How do you stumble across this stuff?

I seem to be good at searching and skimming through research papers. I then pick out concepts/mechanisms/compounds that jump out, and then direct my searches in that direction. It seems to work fairly well for finding new things. Then I download the papers and read them in full w…

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to ABabyAteMyDingo · I don't know anything about MDA, can you explain this? Thanks.

Malondialdehyde is a marker for oxidative stress. If you have higher levels of MDA (I hate their use of this acronym, as it conflicts with methylendioxyamphetamine), then it is a marker that your body is dealing with higher amounts of oxidative stress. Lowering the level of malon…

Yeast production of nicotinamide riboside - Google Patents

Replying to shrillthrill · ah, I'm biased in the other direction away from the alcoholic stuff, I do kefir-brie, paneer, milk-kefir, water kefir (yes, a small alcoholic content, but 1% or something), matsoni…

Nice! Yours would definitely be healthier. Mine would be more fun! I'm actually making a cream ale with Australian Galaxy hops in a couple weeks. It would be a cool test to use this strain.

Are circa 1mg doses of melatonin too wimpy to protect/enhance brain mitochondria?

Replying to timevast · My understanding is that Tryptophan is a precursor to Melatonin and a better strategy. I'm sorrry but I can't post links right now. Maybe someone else will address this.

There are too many rate-limiting enzymes in between tryptophan and melatonin for that kind of supplementation to help in the manner in which we are speaking. We want the ROS scavenging abilities of melatonin. In my opinion, the best way to achieve this is with the new tacrine–mel…

Nootropics for empathy?

Replying to Dr_Bishop · This is kind of random but I've looked into applying for a schedule I license with the DEA. For myself years down the road I'd like to have one and be licensed as a small private r…

I have not. However, if you ever do get setup, I would be interested in working together. We have some new compounds that we want to bring out, and would love to do it with a US-based lab.

Can someone recommend a stack for depression, social anxiety, concentration, motivation?

Replying to modianos · link? you can PM it if you want.

Make sure you read up on it before considering purchasing it. The first link I posted is a very good summary of its mechanisms.

Can someone recommend a stack for depression, social anxiety, concentration, motivation?

Replying to modianos · where do you get tianeptine? is it prescription?

My company Ceretropic sells it in sublingual dropper vials. That is why I put that "advertisement" tag in there. A few other vendors sell it as well, but in bulk powder form. Keep in mind that I would never suggest a supplement just because I sell it. I don't want to come across…

Yeast production of nicotinamide riboside - Google Patents

Replying to shrillthrill · > My question is how hard would it be to culture it so that one sample would last you an indefinite period. I'm not talking about commercial quantities, just personal use. It grow…

Just do a yeast starter with some DME malt like homebrewers do. Then use a conical fermenter so that you can harvest off the yeast for the next batch. Of course I am biased being a homebrewer.