Comment · Tue, June 9, 2026 · ND Owner
Eurycomax - my (almost 1 year update)
Original post in this thread
anexanhume · 23 points
A year ago, my (41M) “male health” stack was black ginger, 1 cap Cistamax, 2 caps Tribugen, and 1 tablet TA 10%. I immediately switched to 2 caps Eurycomax when it launched almost a year ago. The images show my testosterone and free testosterone comparison of early May last year to last week now on Eurycomax. I’m happy to report my own experiential perception of the swap matches the results!
What they were answering
DoctorBoneMarrow · 2 points
Can you tell us more about the protein? What makes it so complex? I've always thought the protein source doesn't matter too much as long as it has a complete amino acid profile.
u/MisterYouAreSoDumb · ND Owner
It matters immensely, because it is not just about having all the amino acids. The ratio of amino acids matters a lot, and the form those amino acids are in (peptide and protein structures). This is party due to the digestibility and bioavailability of the forms, which is measured by PDCAAS or DIAAS. However, it is also just in the nature of the ratios of the specific amino acids themselves. Whey protein has all essential amino acids, but not the ideal ratios. It's high in methionine and cysteine, also called the SAA fraction, or sulfur amino acid fraction. It's actually 52% over the reference range for the SAA fraction, meaning significantly over what is ideal. Why does that matter?
A landmark Lancet study30257-3/fulltext) of 11,576 NHANES participants found that individuals in the lowest SAA intake quintile had significantly lower levels of cholesterol, glucose, HbA1c, uric acid, and insulin, and a meaningfully reduced composite cardiometabolic risk score30257-3/fulltext). Other research shows that methionine restriction by 80% extends average and maximum lifespan by 42–44%. The reason for that is reduced GH/IGF-1 signaling, improved insulin sensitivity, and lower oxidative stress due to not consuming too high of an SAA fraction. This means consuming protein that doesn't overload methionine, unlike whey, is ideal for human health. Then comes leucine.
Leucine is the single most important amino acid for initiating muscle protein synthesis. It is the primary activator of mTORC1, the master regulator of protein synthesis and muscle hypertrophy. The "leucine threshold" for maximal mTORC1 activation is 2.5–3.0 g per meal. Our current working formula is around 2X the reference, which is 20% over whey protein isolate, meaning we will be delivering all the leucine your muscles will need when lifting. Moreover, we are targeting a biphasic leucine curve, with some free leucine to act immediately in the body, then the rest bound up in protein-peptide chains, to deliver sustained release. This will give fast-acting and prolonged mTORC1 activation. Our formula will have more leucine than the highest level whey protein on the market. However, then you get to isoleucine.
Unlike leucine, restricting isoleucine is better. High dietary isoleucine correlates strongly with higher BMI. Blood isoleucine (but not leucine or valine) is positively associated with all-cause mortality in humans, the only BCAA with this association. Restricting isoleucine alone extended male mouse lifespan by 33% and female by 7%, while also reducing frailty, cancer incidence, and prostate enlargement. The mechanism involves FGF21 induction, improved hepatic insulin sensitivity, and enhanced thermogenesis (UCP1 activation). Our formula will have around 15% less isoleucine than whey protein isolate and 22% less than whey protein concentrate. More importantly, the leucine to isoleucine/valine ratio will be much more favorable, which is exactly what the longevity literature suggests is optimal. It maximizes the anabolic signal from leucine while not flooding the body with the BCAAs associated with obesity, insulin resistance, and mortality. Then you get to the aromatic amino acids (AAAs) phenylalanine and tyrosine.
Our formula will have 75% more phenylalanine and tyrosine than whey protein isolate. Phenylalanine is the dietary precursor to tyrosine, which is the rate-limiting substrate for dopamine → norepinephrine → epinephrine synthesis. High AAA availability post-exercise directly supports catecholamine replenishment, thyroid hormone (thyroxine contains iodinated tyrosine residues) synthesis, and melanin production. This is going to be one you can actually feel the benefits for. We are also slightly increasing the amount of tryptophan compared to whey protein isolate, which is what makes serotonin. So our protein will help support mood and motivation better than other proteins.
Then you have peptide, micronutrients, and other signaling molecules that affect how well it works. These are things like lactoferrin, lactalbumin, immunoglobulin, etc. Then you have human milk oligosaccharides, which we are going to probably include. Then we are likely going to be adding in a probiotic that has been shown to improve protein uptake. I could go on for a long time, but you get the idea. We are doing what we did for fiber with InfiniFiber, but to protein. I think a lot of people think protein is protein, just like a lot of people thought fiber was fiber. However, InfiniFiber is our most successful product launch in company history, and we can barely keep it on the shelf. Everyone loves it, because we really thought through the science of fiber. We are doing the same thing here with protein. Not all protein is created equal, and we are going to educate everyone on that.