Comment · Wed, December 11, 2024 · ND Owner
Will taking GABA agonists for sleep downregulate it long term? Advice for the sleep stack supplements please!
Original post in this thread
Obviously1138 · 9 points
I have severe ME/CFS and my insomnia is not something I can cure with lifestlye changes. I rarely use screens and have a good sleep hygiene.
As my illness progressed I started to sleep less, with my problem mostly being waking up during the night. Sometimes after 2 to 4 hours and not being able to fall asleep after.
With supplements, I am able to get decent 6-7 hours meaning I can fall asleep easier when I wake up. I thought about low dose antidepressants because of my chronic condition but my SIBO/gut dysbiosis makes me not a good candidate.
I try to cycle by changing to a different supplement every 4-5 days. Have been wanting to find a bigger rotating stack cause most of these are ineffective if used more than 3 days a month.
But upon reading have found that most of these are either GABA agonist or can in some way downregulate GABA so now I am scared if I am doing that. What are the chances?
Raw-dogging sleep for 4 months worsened my state permanently so that's not an option. I would get 3h of sleep a night.
My stack/schedule is:
- taurine 5 days 1-2g
- L-theanine 4days 250-500 mg
- zopiclone
- glycine 5 days 1-2g
- 5htp 4 days 100-150mmg
- zopiclone
and repeat
Sometimes…
What they were answering
MuscaMurum · 3 points
I've been experimenting with Swanson's Ecklonia Cava extract and a Hops extract with great success. I know that Nootropics Depot is working on EC, but I just took a chance on the Swanson's one and I'm sleeping straight through the night.
I've also had success with Chinese Skullcap in the past. Nootropics Depot's Lucidispore is fantastic, but expensive. Same with their Coriander.
u/MisterYouAreSoDumb · ND Owner
That one we tested, and is NOT Ecklonia cava. We have not been able to figure out what it actually is yet, but we know for certain is it not Ecklonia cava.